About: Alfuzosin Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Alfuzosin Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Alfuzosin Hydrochloride
UMLS_CUI
  • C0102130
CAS_Registry
  • 81403-68-1
FDA_UNII_Code
  • 75046A1XTN
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 465648
PDQ_Closed_Trial_Search_ID
  • 465648
Chemical_Formula
  • C19H27N5O4.ClH
Legacy_Concept_Name
  • Alfuzosin_Hydrochloride
CHEBI_ID
  • CHEBI:32286
FULL_SYN
  • Alfuzosin HydrochloridePTNCI
  • (+/-)-N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide MonohydrochlorideSNNCI
  • ALFUZOSIN HYDROCHLORIDEPTFDA75046A1XTN
  • (R,S)-N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino] propyl]tetrahydro-2-furancarboxamide HydrochlorideSNNCI
  • UroxatralBRNCI
  • SL 77499-10CNNCI
DEFINITION
  • The hydrochloride salt of alfuzosin, a quinazoline compound with smooth muscle-relaxing activity. Alfuzosin selectively binds to and antagonizes post-synaptic alpha-1-adrenoreceptors in smooth muscle of the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra, initiating relaxation of smooth muscle and resulting in improvement of urine flow and the symptoms of benign prostatic hyperplasia (BPH). This agent also blocks alpha-1-adrenoreceptors in peripheral vascular smooth muscle, resulting in vasodilatation and a decrease in peripheral vascular resistance.NCI
code
  • C53408
is Has_Salt_Form of
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