About: Elacytarabine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Elacytarabine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Elacytarabine
UMLS_CUI
  • C1707141
CAS_Registry
  • 188181-42-2
  • 675837-43-1
FDA_UNII_Code
  • TA7WJG93AR
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 463939
PDQ_Closed_Trial_Search_ID
  • 463939
Chemical_Formula
  • C27H45N3O6
Legacy_Concept_Name
  • CP-4055
FULL_SYN
  • ELACYTARABINEPTFDATA7WJG93AR
  • 4-amino-1-[5-O-[(9E)-octadec-9-enoyl]-beta-D-arabinofuranosyl]pyrimidin-2(1H)-oneSNNCI
  • ElacytarabinePTNCI
  • ElacytBRNCI
  • CP-4055CNNCI
DEFINITION
  • The lipophilic 5'-elaidic acid ester of the deoxycytidine analog cytosine arabinoside (cytarabine; Ara-C) with potential antineoplastic activity. As a prodrug, elacytarabine is converted intracellularly into cytarabine triphosphate by deoxycytidine kinase and subsequently competes with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis. Compared to cytarabine, elacytarabine shows increased cellular uptake and retention, resulting in increased activation by deoxycytidine kinase to cytarabine triphosphate, decreased deamination and deactivation by deoxycytidine deaminase, and increased inhibition of DNA synthesis. This agent also inhibits RNA synthesis, an effect not seen with cytarabine.NCI
code
  • C53401
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