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AttributesValues
rdf:type
rdfs:label
  • Dacomitinib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dacomitinib
UMLS_CUI
  • C1709400
CAS_Registry
  • 1042385-75-0
FDA_UNII_Code
  • 5092U85G58
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein tyrosine kinase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 462567
PDQ_Closed_Trial_Search_ID
  • 462567
Chemical_Formula
  • C24H25ClFN5O2.H2O
Legacy_Concept_Name
  • PF-00299804
FULL_SYN
  • DacomitinibPTNCI
  • (2E)-N-(4-((3-Chloro-4-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-yl)-4-Piperidin-1-ylbut-2-EnamideSNNCI
  • PF-299804CNNCI
  • PF-00299804CNNCI
  • PF-00299804-03CNNCI
  • EGFR Inhibitor PF-00299804SYNCI
  • DACOMITINIBPTFDA5092U85G58
  • PF-00299804PTNCI-GLOSSCDR0000468787
DEFINITION
  • A highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors.NCI
code
  • C53398
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