About: ABCC1 wt Allele     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • ABCC1 wt Allele
equivalentClass
OMIM_Number
  • 158343
GenBank_Accession_Number
  • NM_004996
Semantic_Type
  • Gene or Genome
Preferred_Name
  • ABCC1 wt Allele
UMLS_CUI
  • C1704873
GO_Annotation
  • ATP bindingGO:0005524TAS29-SEP-2003CGAP
  • ATP-binding cassette (ABC) transporter activityGO:0004009TAS29-SEP-2003CGAP
  • integral to plasma membraneGO:0005887TAS29-SEP-2003CGAP
  • membrane fractionGO:0005624TAS29-SEP-2003CGAP
  • transportGO:0006810TAS29-SEP-2003CGAP
  • drug resistanceGO:0009315TAS29-SEP-2003CGAP
  • transporter activityGO:0005215TAS29-SEP-2003CGAP
EntrezGene_ID
  • 4363
Legacy_Concept_Name
  • ABCC1_wt_Allele
HGNC_ID
  • HGNC:51
FULL_SYN
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 wt AlleleSYNCI
  • ABCC1 wt AllelePTNCI
  • MRPSYNCI
  • ABCCSYNCI
  • GS-XSYNCI
  • MRP1SYNCI
  • ABC29SYNCI
  • ABCC1SYNCI
Gene_Encodes_Product
  • Multiple Drug Resistance-Associated Protein
DEFINITION
  • Human ABCC1 wild-type allele is located in the vicinity of 16p13.1 and is approximately 193 kb in length. This allele, which encodes multidrug resistance-associated protein 1, is involved in multispecific organic anion transport.NCI
DesignNote
  • Expressed in lung, testis, and peripheral blood mononuclear cells, the 200 kb human MRP1 Gene (ABC family) at 16p13.1 - telomeric to MYH11 - contains thirty-one exons that encode a plasma membrane drug-efflux transporter associated with multidrug resistance. A 7.8-8.2 kb mRNA is transcribed and several variant transcripts maintain the open reading frame. MRP1 contains a high proportion of class 0 introns. Conservation of intron/exon organization and sequence suggest that MRP-related transporters evolved by fusion from a shared common ancestor with CFTR and MDR1 encoding polytopic membrane proteins. MRP1 also appears to regulate LTC4 transport, which promotes chemotaxis to CCL19 and dendritic cell migration to lymph nodes. MRP1 is over expressed in a multidrug-resistant SCLC cell line.
code
  • C52275
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