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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Atiprimod
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Atiprimod
UMLS_CUI
  • C1579206
CAS_Registry
  • 123018-47-3
FDA_UNII_Code
  • MG7D3QD743
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. SK&F106615 may block the growth of tumors and may prevent the growth of new blood vessels that tumors need to grow. SK&F106615 is a type of signal transduction inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 382134
PDQ_Closed_Trial_Search_ID
  • 382134
Chemical_Formula
  • C22H44N2
Legacy_Concept_Name
  • Atiprimod
FULL_SYN
  • azaspiranePTNCI-GLOSSCDR0000523287
  • ATIPRIMODPTFDAMG7D3QD743
  • N,N-Diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamineSNNCI
  • SK&F106615PTNCI-GLOSSCDR0000523288
  • Azaspirane SK&F106615SYNCI
  • AtiprimodPTNCI
  • SK&F106615CNNCI
  • atiprimodPTNCI-GLOSSCDR0000486451
DEFINITION
  • An orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis.NCI
code
  • C52184
is Has_Free_Acid_Or_Base_Form of
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