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AttributesValues
rdf:type
rdfs:label
  • Broccoli Sprout Extract
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Broccoli Sprout Extract
UMLS_CUI
  • C1707048
ALT_DEFINITION
  • A substance being studied in the prevention of cancer. Broccoli sprout extract comes from newly sprouted broccoli. It causes cells to make enzymes that may protect them against cancer-causing toxins in the body, and it may also block the growth of cancer cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 455271
PDQ_Closed_Trial_Search_ID
  • 455271
Legacy_Concept_Name
  • Broccoli_Sprout_Extract
FULL_SYN
  • Broccoli Sprout ExtractPTNCI
  • broccoli sprout extractPTNCI-GLOSSCDR0000560643
DEFINITION
  • A cruciferous vegetable extract with potential chemopreventive activities. Broccoli sprout extract contains a high amount of sulforaphane, a naturally occurring isothiocyanate. Sulforaphane activates the transcription factor NF-E2-related factor 2 (Nrf2), a member of the basic leucine zipper family, which binds to and activates antioxidant-response elements (AREs). Subsequently, activated AREs mediate the transcription of antioxidant enzymes (particularly glutathione-S-transferase and quinone oxidoreductase), resulting in the detoxification of highly reactive carcinogens. AREs are cis-acting regulatory enhancer elements found in the 5' flanking region of many phase II detoxification enzymes.NCI
code
  • C52174
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