About: HMGA1 wt Allele     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HMGA1 wt Allele
equivalentClass
OMIM_Number
  • 600701
GenBank_Accession_Number
  • NM_002131
Semantic_Type
  • Gene or Genome
Preferred_Name
  • HMGA1 wt Allele
UMLS_CUI
  • C1708280
GO_Annotation
  • DNA bindingGO:0003677TAS29-SEP-2003CGAP
  • regulation of transcription, DNA-dependentGO:0006355TAS29-SEP-2003CGAP
  • AT DNA bindingGO:0003680TAS29-SEP-2003CGAP
EntrezGene_ID
  • 3159
Legacy_Concept_Name
  • HMGA1_wt_Allele
HGNC_ID
  • HGNC:5010
FULL_SYN
  • MGC4242 GeneSYNCI
  • MGC4854 GeneSYNCI
  • High Mobility Group Protein HMG-I/HMG-Y GeneSYNCI
  • MGC12816 GeneSYNCI
  • HMG-I(Y) GeneSYNCI
  • HMGA1 wt AllelePTNCI
  • High Mobility Group AT-Hook 1 wt AlleleSYNCI
  • High Mobility Group Protein HMGI-Y GeneSYNCI
  • High Mobility Group Protein Isoforms I and Y GeneSYNCI
  • Nonhistone Chromosomal High-Mobility Group Protein HMG-I/HMG-Y GeneSYNCI
  • HMG-R GeneSYNCI
  • HMGIY GeneSYNCI
Gene_Encodes_Product
  • HMGA1a
  • HMGA1b
  • HMGA1c
DEFINITION
  • Human HMGA1 wild-type allele is located within 6p21 and is approximately 9 kb in length. This allele, which encodes high mobility group protein HMG-I/HMG-Y, is involved in chromatin remodeling, DNA-dependent transcriptional regulation and inhibition of tumor suppressor p53 protein-dependent apoptosis. The HMGA1 gene is overexpressed in certain types of cancer including breast carcinoma, colorectal cancer, non-small-cell lung carcinoma, epithelial ovarian carcinoma and thyroid cancer.NCI
DesignNote
  • This gene may play a role in both nucleosome phasing and processing of the 3' end of mRNA transcripts. Defects in the HMGA1 gene are suggested to cause both decreased insulin receptor expression and induction of insulin resistance.
code
  • C52074
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