About: IL8RB wt Allele     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • IL8RB wt Allele
equivalentClass
OMIM_Number
  • 146928
GenBank_Accession_Number
  • NM_001557
Semantic_Type
  • Gene or Genome
Preferred_Name
  • IL8RB wt Allele
UMLS_CUI
  • C1704986
GO_Annotation
  • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)GO:0007200TAS29-SEP-2003CGAP
  • interleukin-8 receptor activityGO:0004918TAS29-SEP-2003CGAP
  • signal transducer activityGO:0004871TAS29-SEP-2003CGAP
  • inflammatory responseGO:0006954TAS29-SEP-2003CGAP
  • integral to plasma membraneGO:0005887TAS29-SEP-2003CGAP
  • cell proliferationGO:0008283TAS29-SEP-2003CGAP
  • cell motilityGO:0006928TAS29-SEP-2003CGAP
  • G-protein coupled receptor protein signaling pathwayGO:0007186TAS29-SEP-2003CGAP
  • cell surface receptor linked signal transductionGO:0007166TAS29-SEP-2003CGAP
  • signal transductionGO:0007165TAS29-SEP-2003CGAP
  • cytoplasmGO:0005737TAS29-SEP-2003CGAP
  • cellular defense responseGO:0006968TAS29-SEP-2003CGAP
  • plasma membraneGO:0005886TAS29-SEP-2003CGAP
  • chemotaxisGO:0006935TAS29-SEP-2003CGAP
EntrezGene_ID
  • 3579
Legacy_Concept_Name
  • IL8RB_wt_Allele
HGNC_ID
  • HGNC:6027
FULL_SYN
  • IL8RB wt AllelePTNCI
  • IL8R2SYNCI
  • CXCR2SYNCI
  • Interleukin 8 Receptor, Beta wt AlleleSYNCI
  • CMKAR2SYNCI
  • CDw128bSYNCI
Gene_Encodes_Product
  • Interleukin 8 Receptor Beta
DEFINITION
  • Human IL8RB wild-type allele is located within 2q35 and is approximately 11 kb in length. This allele, which encodes high affinity interleukin-8 receptor B protein, is involved in the mediation of neutrophil migration to sites of inflammation, cellular growth, and angiogenic effects in intestinal microvascular endothelial cells. Allelic variants of the gene are associated with serum-dependent melanoma cell growth.NCI
DesignNote
  • Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration.
code
  • C51372
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 11 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software