About: RPSA wt Allele     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • RPSA wt Allele
equivalentClass
OMIM_Number
  • 150370
GenBank_Accession_Number
  • NM_002295
Semantic_Type
  • Gene or Genome
Preferred_Name
  • RPSA wt Allele
UMLS_CUI
  • C1705231
GO_Annotation
  • integral to plasma membraneGO:0005887NR29-SEP-2003CGAP
  • cell adhesionGO:0007155NR29-SEP-2003CGAP
  • cell surface receptor linked signal transductionGO:0007166NR29-SEP-2003CGAP
  • laminin receptor proteinGO:0005613NR29-SEP-2003CGAP
  • cytosolic small ribosomal subunit (sensu Eukarya)GO:0005843NR29-SEP-2003CGAP
  • regulation of translationGO:0006445NR29-SEP-2003CGAP
  • invasive growthGO:0007125NR29-SEP-2003CGAP
  • laminin receptor activityGO:0005055TAS29-SEP-2003CGAP
EntrezGene_ID
  • 3921
Legacy_Concept_Name
  • LAMR1_wt_Allele
HGNC_ID
  • HGNC:6502
FULL_SYN
  • RPSA wt AllelePTNCI
  • p40SYNCI
  • LRPSYNCI
  • 67LRSYNCI
  • 37LRPSYNCI
  • LAMR1SYNCI
  • LAMBRSYNCI
  • Ribosomal Protein SA wt AlleleSYNCI
  • LAMR1 GeneSYNCI
Gene_Encodes_Product
  • Laminin Receptor-1
DEFINITION
  • Human RPSA wild-type allele is located in the vicinity of 3p22.2 and is approximately 6 kb in length. This allele, which encodes 40S ribosomal protein SA, plays a role in a variety of biological processes that are mediated by interactions with cell surface receptors.NCI
DesignNote
  • The 5.7-kb human LAMR1 Gene (Non-Integrin Family, S2P Family) at 3p21.3 contains a promoter with 4 Sp1 sites, multiple TSS, and seven exons that yield a 1.2-kb transcript encoding a conserved 295-amino acid 37-kD multifunctional protein with a negative C-terminal segment, amphipathic alpha-helices, and N-glycosylation sites. GNRH2 or GNRH1 trigger transcription. GC-rich intron 1 contains 5 Sp1 sites, intron 3 contains 2 Alu sequences, and intron 4 contains snRNA E2. Multiple retropositional pseudogenes exist; 16-21 copies per human or mouse haploid genome. Identical to 40S Ribosomal Protein SA, the encoded heterodimeric 67-kD Laminin Receptor-1 precursor is involved in translation and cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Gene expression in cancer cells correlates with invasive/metastatic phenotype.
code
  • C51313
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