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AttributesValues
rdf:type
rdfs:label
  • Flucytosine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Flucytosine
NSC_Code
  • 103805
UMLS_CUI
  • C0016278
CAS_Registry
  • 2022-85-7
FDA_UNII_Code
  • D83282DT06
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that treats infections caused by fungi.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41023
PDQ_Closed_Trial_Search_ID
  • 41023
Chemical_Formula
  • C4H4FN3O
Legacy_Concept_Name
  • Flucytosine
CHEBI_ID
  • CHEBI:5100
FULL_SYN
  • FlucytosinePTNCI
  • 4-Amino-5-fluoro-2(1H)-pyrimidinoneSNNCI
  • 4-Amino-5-fluoro-2(1H)-pyrimidinoneSYDTPNSC0103805
  • flucytosinePTNCI-GLOSSCDR0000045330
  • 5-FCABNCI
  • AncobonSYDTPNSC0103805
  • AncotilSYDTPNSC0103805
  • 5-FluorocytosineSNNCI
  • Ro 2-9915SYDTPNSC0103805
  • 5-FluorocytosineSYDTPNSC0103805
  • AlcobonFBNCI
  • AncobonBRNCI
  • AncotilFBNCI
  • Ro-2-9915CNNCI
  • FLUCYTOSINEPTFDAD83282DT06
  • 5-FCSYDTPNSC0103805
DEFINITION
  • A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.NCI
code
  • C501
is someValuesFrom of
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