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AttributesValues
rdf:type
rdfs:label
  • Fluconazole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Fluconazole
UMLS_CUI
  • C0016277
CAS_Registry
  • 86386-73-4
Accepted_Therapeutic_Use_For
  • Antifungal, prophylaxis in allogeneic bone marrow transplantation; Candidiasis; Cryptococcal meningitis
In_Clinical_Trial_For
  • Chemotherapy-induced fungal infections
FDA_UNII_Code
  • 8VZV102JFY
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that treats infections caused by fungi.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40842
PDQ_Closed_Trial_Search_ID
  • 40842
Chemical_Formula
  • C13H12F2N6O
Legacy_Concept_Name
  • Fluconazole
CHEBI_ID
  • CHEBI:46081
FULL_SYN
  • FluconazolePTNCI
  • fluconazolePTNCI-GLOSSCDR0000045320
  • DiflucanBRNCI
  • FLUCONAZOLEPTFDA8VZV102JFY
  • alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanolSNNCI
DEFINITION
  • A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.NCI
code
  • C500
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