About: CCNE2 wt Allele     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CCNE2 wt Allele
equivalentClass
OMIM_Number
  • 603775
GenBank_Accession_Number
  • NM_004702
Semantic_Type
  • Gene or Genome
Preferred_Name
  • CCNE2 wt Allele
UMLS_CUI
  • C1707089
GO_Annotation
  • cell cycle checkpointGO:0000075TAS29-SEP-2003CGAP
  • regulation of CDK activityGO:0000079TAS29-SEP-2003CGAP
EntrezGene_ID
  • 9134
Legacy_Concept_Name
  • CCNE2_wt_Allele
HGNC_ID
  • HGNC:1590
FULL_SYN
  • DDH1SYNCI
  • CCNE2 wt AllelePTNCI
  • Cyclin E2 wt AlleleSYNCI
Gene_Encodes_Product
  • Cyclin E2
DEFINITION
  • Human CCNE2 wild-type allele is located in the vicinity of 8q22.1 and is approximately 15 kb in length. This allele, which encodes G1/S-specific cyclin-E2 protein, is involved in the regulation of the G1/S transition of the cell cycle. The expression of this allele peaks at the G1-S phase and has distinct tissue specificity.NCI
DesignNote
  • CCNE2 is upregulated by E6 and E7 and the tissue expression pattern at the G1/S peak is distinct from CCNE1. The gene is consistently elevated in tumor cell lines. Splice variants encode 2 distinct nuclear CCNE2 isoforms.
code
  • C49527
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