About: BCL2L11 wt Allele     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • BCL2L11 wt Allele
equivalentClass
OMIM_Number
  • 603827
GenBank_Accession_Number
  • NM_207003
Semantic_Type
  • Gene or Genome
Preferred_Name
  • BCL2L11 wt Allele
UMLS_CUI
  • C1706320
GO_Annotation
  • membrane fractionGO:0005624TAS29-SEP-2003CGAP
  • induction of apoptosisGO:0006917TAS29-SEP-2003CGAP
EntrezGene_ID
  • 10018
Legacy_Concept_Name
  • BCL2L11_wt_Allele
HGNC_ID
  • HGNC:994
FULL_SYN
  • BCL2-like 11 (Apoptosis Facilitator) wt AlleleSYNCI
  • BAMSYNCI
  • BODSYNCI
  • BIMSYNCI
  • BIMLSYNCI
  • BCL2L11 wt AllelePTNCI
  • BIMELSYNCI
  • BimMELSYNCI
  • BCL-2-Related Ovarian Death Agonist GeneSYNCI
Gene_Encodes_Product
  • BCL2-Related Protein 11
DEFINITION
  • Human BCL2L11 wild-type allele is located in the vicinity of 2q13 and is approximately 40 kb in length. This allele, which encodes Bcl-2-like protein 11, is an apoptotic activator and plays a role in neuronal and lymphocyte apoptosis.NCI
DesignNote
  • BCL2L11has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of the apoptosis in thymocyte-negative selection and eight alternatively spliced transcript variants of this gene have been reported.
code
  • C49370
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