About: Recombinant Adenovirus-L523S Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Adenovirus-L523S Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Adenovirus-L523S Vaccine
UMLS_CUI
  • C1328161
PDQ_Open_Trial_Search_ID
  • 353187
PDQ_Closed_Trial_Search_ID
  • 353187
Legacy_Concept_Name
  • Recombinant_Adenovirus-L523S_Vaccine
FULL_SYN
  • Recombinant Adenovirus-L523S VaccinePTNCI
  • Ad/L523SABNCI
DEFINITION
  • A replication-defective adenovirus containing a gene that encodes the human protein L523S with potential antineoplastic activity. Upon administration, recombinant adenovirus-L523S vaccine expresses L523S, which may stimulate antibody and cytotoxic T lymphocyte (CTL) responses against tumor cells expressing L523S. L523S is an RNA-binding protein that belongs to the KOC (K homology domain containing protein over-expressed in cancer) family of proteins. As an oncofetal protein, L523S is normally expressed in early embryonic tissues and certain normal adult tissues such as colon, fallopian tube, gall bladder, and ovary tissues but may be overexpressed in squamous cell cancers of the lung.NCI
code
  • C49289
is someValuesFrom of
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