About: Fluorothymidine F-18     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fluorothymidine F-18
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fluorothymidine F-18
UMLS_CUI
  • C1432709
CAS_Registry
  • 287114-80-1
FDA_UNII_Code
  • 2X1K91UT6N
Contributing_Source
  • FDA
ALT_DEFINITION
  • A radioactive substance being studied in the diagnosis of cancer. 18F-FLT is injected into the blood and builds up in cells that are dividing, including cancer cells. The radiation that it gives off as it decays (breaks down) helps make clear pictures of tumors during positron emission tomography (PET) scans. It is a type of radiopharmaceutical.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 453547
PDQ_Closed_Trial_Search_ID
  • 453547
Chemical_Formula
  • C10H13FN2O4
Legacy_Concept_Name
  • _18F-FLT
FULL_SYN
  • Thymidine, 3'-deoxy-3'-(18F)fluoro-SNNCI
  • 3'-deoxy-3'-(18F) fluorothymidinePTNCI-GLOSSCDR0000597239
  • fluorothymidine F 18PTNCI-GLOSSCDR0000468784
  • 18F-FLTPTNCI-GLOSSCDR0000597240
  • 18F-FLTSYNCI
  • Fluorothymidine F-18PTNCI
  • 3'-deoxy-3'-[18F]fluorothymidineSYNCI
  • FLUOROTHYMIDINE F-18PTFDA2X1K91UT6N
DEFINITION
  • A radioconjugate consisting of a thymidine analogue radiolabeled with fluorine F 18, a positron emitting isotope. Phosphorylated by S-phase-specific thymidine kinase 1, 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) is trapped intracellularly by entering the salvage pathway of DNA synthesis without incorporation into DNA. 18F-FLT serves a marker of tumor cell proliferation for imaging with positron emission tomography (PET); as a marker of proliferation rather than metabolism, it is more specific to tumor tissue than 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG). This agent is metabolically stable, accumulates in the normal bone marrow and the liver, and does not cross the blood-brain barrier.NCI
code
  • C49093
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