About: Immunomodulator OHR/AVR118     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Immunomodulator OHR/AVR118
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Immunomodulator OHR/AVR118
UMLS_CUI
  • C1172837
PDQ_Open_Trial_Search_ID
  • 453546
  • 686449
PDQ_Closed_Trial_Search_ID
  • 453546
  • 686449
Legacy_Concept_Name
  • AVR118
FULL_SYN
  • Immunomodulator OHR/AVR118PTNCI
  • AVR118CNNCI
  • Product RSYNCI
DEFINITION
  • A broad-spectrum peptide nucleic acid formulation comprised of breakdown products of casein, peptone, RNA and serum albumin, with potential anti-inflammatory, immunomodulatory, anti-anorectic and anti-cachexia activities. AVR118 mainly contains two peptides, peptide A and peptide B, in approximately a 1:1 ratio: peptide A (31 a. a.) is derived from bovine casein; peptide B (21 a. a.) is covalently linked via phosphodiester bond to a diadenosine unit. In addition, AVR118 contains nucleosides, nucleoside diphosphates and nucleoside monophosphates. Upon subcutaneous injection of AVR118, this agent affects the synthesis of many pro-inflammatory chemokines and cytokines, especially monocyte chemotactic protein-1 (MCP-1), interleukin (IL)-8, IL-1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha). In particular, AVR118 stimulates macrophages to produce these mediators while in highly activated macrophages this agent inhibits their synthesis. This way, AVR118 may prevent the excessive release of cytokines seen during chemotherapy. Controlling the release of pro-inflammatory mediators may ultimately improve appetite and mood, increase strength and weight gain, and decrease fatigue.NCI
code
  • C49092
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