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AttributesValues
rdf:type
rdfs:label
  • APC8015F
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • APC8015F
UMLS_CUI
  • C1541593
In_Clinical_Trial_For
  • Prostate Cancer
ALT_DEFINITION
  • A vaccine made from immune system cells taken from a patient with prostate cancer and frozen for future use. The cells are treated in the laboratory with a growth factor attached to a protein called prostatic-acid phosphatase (PAP), which is found on prostate cancer cells. When APC8015F is injected into the patient, it may cause T cells (a type of white blood cell) to kill tumor cells that have PAP on them.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 385490
PDQ_Closed_Trial_Search_ID
  • 385490
Legacy_Concept_Name
  • APC8015F
FULL_SYN
  • APC8015FPTNCI-GLOSSCDR0000561410
  • APC8015FCNNCI
  • APC8015FPTNCI
  • APC 8015FCNNCI
DEFINITION
  • A cell-based vaccine composed of previously frozen autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP.NCI
code
  • C48640
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