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AttributesValues
rdf:type
rdfs:label
  • Larotaxel
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Larotaxel
UMLS_CUI
  • C0392979
CAS_Registry
  • 156294-36-9
FDA_UNII_Code
  • TWQ8K8A81Y
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of breast cancer. It belongs to the family of drugs called taxane derivatives.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42554
PDQ_Closed_Trial_Search_ID
  • 42554
Chemical_Formula
  • C45H53NO14
Legacy_Concept_Name
  • XRP9881
FULL_SYN
  • RPR 109881APTNCI-GLOSSCDR0000045512
  • Taxoid-109881CNNCI
  • XRP9881PTNCI-GLOSSCDR0000430877
  • LAROTAXELPTFDATWQ8K8A81Y
  • LarotaxelPTNCI
  • RPR-109881CNNCI
  • RPR 109881ACNNCI
DEFINITION
  • A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.NCI
code
  • C48427
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