About: Oncolytic Adenovirus Encoding GM-CSF     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oncolytic Adenovirus Encoding GM-CSF
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Oncolytic Adenovirus Encoding GM-CSF
UMLS_CUI
  • C1709316
PDQ_Open_Trial_Search_ID
  • 434519
PDQ_Closed_Trial_Search_ID
  • 434519
Legacy_Concept_Name
  • Oncolytic_Adenovirus_Encoding_GM-CSF
FULL_SYN
  • Oncolytic Adenovirus Encoding GM-CSFPTNCI
  • CG0070CNNCI
DEFINITION
  • A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, the oncolytic adenovirus selectively infects and replicates in tumor cells, which may result in tumor cells lysis. Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death.NCI
code
  • C48412
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