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AttributesValues
rdf:type
rdfs:label
  • Therapeutic Estrone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Therapeutic Estrone
NSC_Code
  • 9699
UMLS_CUI
  • C0014942
CAS_Registry
  • 53-16-7
FDA_UNII_Code
  • 2DI9HA706A
Contributing_Source
  • FDA
Chemical_Formula
  • C18H22O2
Legacy_Concept_Name
  • Therapeutic_Estrone
CHEBI_ID
  • CHEBI:17263
FULL_SYN
  • ESTRONEPTFDA2DI9HA706A
  • TheelinSYDTPNSC0009699
  • TheelinSYNCI
  • EstroneSYNCI
  • Therapeutic EstronePTNCI
  • OestroneSYNCI
  • EstronePTDCP01201
DEFINITION
  • The synthetic form of a naturally occurring estrogen estrone. Estrone diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated hormone-receptor complex gets translocated to the nucleus where it binds to the estrogen response element on the DNA and promotes the transcription of target genes involved in the functioning of the female reproductive system and secondary sex characteristics. Estrone increases the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins, as well as suppresses the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.NCI
code
  • C484
is Has_Free_Acid_Or_Base_Form of
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