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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ingenol Mebutate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ingenol Mebutate
PubMedID_Primary_Reference
  • 19178487
UMLS_CUI
  • C1452152
CAS_Registry
  • 75567-37-2
FDA_UNII_Code
  • 7686S50JAH
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 432941
PDQ_Closed_Trial_Search_ID
  • 432941
Chemical_Formula
  • C25H34O6
Legacy_Concept_Name
  • Ingenol_3-Angelate
FULL_SYN
  • I3AABNCI
  • INGENOL MEBUTATEPTFDA7686S50JAH
  • Ingenol MebutatePTNCI
  • PEP005CNNCI
  • Ingenol-3-AngelateSYNCI
  • Ingenol-3-angelateSYNCI
  • PEP-005CNNCI
  • 2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a- octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a- methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)-SNNCI
DEFINITION
  • A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol mebutate activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis.NCI
code
  • C48398
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