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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Degarelix
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Degarelix
UMLS_CUI
  • C0971731
CAS_Registry
  • 214766-78-6
Accepted_Therapeutic_Use_For
  • advanced prostate cancer
FDA_UNII_Code
  • SX0XJI3A11
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat advanced prostate cancer and is also being studied in the treatment of benign prostatic hyperplasia. Degarelix binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. This causes the body to stop making testosterone, which prostate cancer needs to grow. Degarelix is a type of GnRH antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 441235
PDQ_Closed_Trial_Search_ID
  • 441235
Chemical_Formula
  • C82H103ClN18O16
Legacy_Concept_Name
  • Degarelix
FULL_SYN
  • N-acetyl-3-(naphtalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-4-((((4S)-2,6-dioxohexahydropyrimidin-4-yl)carbonyl)amino)-L-phenylalanyl-4-(carbamoylamino)-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-D-alaninamideSNNCI
  • DEGARELIXPTFDASX0XJI3A11
  • FE200486CNNCI
  • FirmagonFBNCI
  • DegarelixPTNCI
  • degarelixPTNCI-GLOSSCDR0000631495
DEFINITION
  • A long-acting, synthetic peptide with gonadotrophin-releasing hormone (GnRH) antagonistic properties. Degarelix targets and blocks GnRH receptors located on the surfaces of gonadotroph cells in the anterior pituitary, thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes.NCI
code
  • C48385
is Has_Free_Acid_Or_Base_Form of
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