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AttributesValues
rdf:type
rdfs:label
  • Talabostat
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Talabostat
UMLS_CUI
  • C2002307
CAS_Registry
  • 149682-77-9
FDA_UNII_Code
  • KZ1O2SH88Z
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer, including certain types of lung, pancreas, and brain cancer. Talabostat may help the immune system block the growth of cancer cells. It may also increase the growth of new blood cells. It is a type of enzyme inhibitor.NCI-GLOSS
Chemical_Formula
  • C9H19BN2O3
Legacy_Concept_Name
  • Talabostat
FULL_SYN
  • talabostatPTNCI-GLOSSCDR0000489304
  • PT-100PTNCI-GLOSSCDR0000523315
  • [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acidSNNCI
  • PT-100CNNCI
  • TALABOSTATPTFDAKZ1O2SH88Z
  • TalabostatPTNCI
DEFINITION
  • A small molecule with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines.NCI
code
  • C48264
is Has_Free_Acid_Or_Base_Form of
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