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AttributesValues
rdf:type
rdfs:label
  • Estrogens, Conjugated
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Estrogens, Conjugated
NSC_Code
  • 18313
UMLS_CUI
  • C0014938
CAS_Registry
  • 12126-59-9
Accepted_Therapeutic_Use_For
  • Advanced androgen-dependent prostate cancer, palliative; Breast cancer, palliative; Estrogen replacement; Menopausal symptoms; Postmenopausal osteoporosis
In_Clinical_Trial_For
  • Menopausal symptoms; osteoporosis, chemotherapy-induced
FDA_UNII_Code
  • IU5QR144QX
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39237
PDQ_Closed_Trial_Search_ID
  • 39237
Legacy_Concept_Name
  • Conjugated_Estrogens
FULL_SYN
  • ATC:G03CA57CNNCI
  • ESTROGENS, CONJUGATEDPTFDAIU5QR144QX
  • PremarinSYDTPNSC0018313
  • Tag-39CNNCI
  • FemestBRNCI
  • PremarinBRNCI
  • Conjugated EstrogensSYNCI
  • ConestronFBNCI
  • SodestrinFBNCI
  • Estrogens, ConjugatedPTNCI
DEFINITION
  • Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. (NCI04)NCI
code
  • C482
is rdfs:subClassOf of
is someValuesFrom of
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