About: Cholecalciferol     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cholecalciferol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Vitamin
Preferred_Name
  • Cholecalciferol
NSC_Code
  • 375571
UMLS_CUI
  • C0008318
CAS_Registry
  • 67-97-0
FDA_UNII_Code
  • 1C6V77QF41
Contributing_Source
  • CRCH
  • FDA
ALT_DEFINITION
  • A nutrient that the body needs in small amounts to function and stay healthy. Cholecalciferol helps the body use calcium and phosphorus to make strong bones and teeth. It is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, egg yolks, and dairy products. Skin exposed to sunshine can also make cholecalciferol. Not enough cholecalciferol can cause a bone disease called rickets. It is being studied in the prevention and treatment of some types of cancer.NCI-GLOSS
  • Vitamin D synthesized from ergosterol in yeast and plants.CRCH
PDQ_Open_Trial_Search_ID
  • 39734
PDQ_Closed_Trial_Search_ID
  • 39734
Chemical_Formula
  • C27H44O
Unit
  • mcg
Legacy_Concept_Name
  • Cholecalciferol
CHEBI_ID
  • CHEBI:28940
FULL_SYN
  • 9,10-Secocholesta-5,7,10(19)-trien-3-beta-olSNNCI
  • Vitamin D3PTCRCH
  • CHOLECALCIFEROLPTFDA1C6V77QF41
  • CholecalciferolPTNCI
  • CholecalciferolSYCRCH
  • CholecalciferolSYDTPNSC0375571
  • 9,10-Secocholesta-5,7,10(19)-trien-3-olSYCRCH
  • CalciolSYNCI
  • cholecalciferolPTNCI-GLOSSCDR0000427252
  • CholecalciferolPTDCP00678
  • (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-olSNNCI
  • DelsterolSYNCI
  • Vitamin D3SYNCI
DEFINITION
  • A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption.NCI
code
  • C48194
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