About: Ziprasidone Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ziprasidone Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ziprasidone Hydrochloride
UMLS_CUI
  • C0380392
CAS_Registry
  • 122883-93-6
  • 138982-67-9
FDA_UNII_Code
  • 216X081ORU
Contributing_Source
  • FDA
Chemical_Formula
  • C21H21ClN4OS.ClH.H2O
Legacy_Concept_Name
  • Ziprasidone_Hydrochloride
CHEBI_ID
  • CHEBI:32314
FULL_SYN
  • Ziprasidone HydrochloridePTNCI
  • Geodon, CapsulesBRNCI
  • ZIPRASIDONE HYDROCHLORIDEPTFDA216X081ORU
  • 5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-Indol-2-one MonohydrochlorideSNNCI
DEFINITION
  • The hydrochloride salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone hydrochloride functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone hydrochloride also inhibits synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone hydrochloride exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors.NCI
code
  • C48031
is Has_Salt_Form of
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