About: Quinidine Sulfate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Quinidine Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Quinidine Sulfate
NSC_Code
  • 10004
UMLS_CUI
  • C1564021
CAS_Registry
  • 6591-63-5
FDA_UNII_Code
  • J13S2394HE
Contributing_Source
  • FDA
Chemical_Formula
  • 2C20H24N2O2.2H2O.H2SO4
Legacy_Concept_Name
  • Quinidine_Sulfate
CHEBI_ID
  • CHEBI:28482
FULL_SYN
  • Quinidine SulfatePTNCI
  • QUINIDINE SULFATEPTFDAJ13S2394HE
  • (9S)-6'-Methoxycinchonan-9-ol Sulfate (2:1) (salt)SNNCI
  • QuinidexBRNCI
DEFINITION
  • The sulfate salt form of quinidine, an alkaloid with antimalarial and antiarrhythmic (Class la) properties. Quinidine sulfate exerts its anti-malarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the hemepolymer (hemozoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. Quinidine sulfate exerts its antiarrhythmic effects by depressing the flow of sodium ions into cells during phase 0 of the cardiac action potential, thereby slowing the impulse conduction through the atrioventricular (AV) node, reducing the rate of phase 0 depolarization and prolonging the refractory period. Quinidine sulfate also reduces the slope of phase 4 depolarization in Purkinje-fibres resulting in slowed conduction and reduced automaticity in the heart.NCI
code
  • C48014
is Has_Salt_Form of
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