About: Melphalan Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Melphalan Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Melphalan Hydrochloride
NSC_Code
  • 241286
UMLS_CUI
  • C0771055
CAS_Registry
  • 3223-07-2
FDA_UNII_Code
  • 1VXP4V453T
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.NCI-GLOSS
Chemical_Formula
  • C13H18Cl2N2O2.HCl
Legacy_Concept_Name
  • Melphalan_Hydrochloride
FULL_SYN
  • 3-(p-(bis(2-chloroethyl)amino)phenyl)-L-Alanine, HydrochlorideSNNCI
  • Melphalan HydrochloridePTNCI
  • MELPHALAN HYDROCHLORIDEPTFDA1VXP4V453T
  • AlkeranPTNCI-GLOSSCDR0000413941
  • AlkeranBRNCI
  • AlkeranaFBNCI
DEFINITION
  • A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death.NCI
code
  • C48002
is Has_Salt_Form of
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