About: Estramustine Phosphate Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Estramustine Phosphate Sodium
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Estramustine Phosphate Sodium
NSC_Code
  • 89199
UMLS_CUI
  • C0014922
CAS_Registry
  • 52205-73-9
FDA_UNII_Code
  • 75F375MT2N
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39235
PDQ_Closed_Trial_Search_ID
  • 39235
Chemical_Formula
  • C23H30Cl2NO6P.2Na
Legacy_Concept_Name
  • Estramustine_Phosphate_Sodium
CHEBI_ID
  • CHEBI:31562
FULL_SYN
  • Estramustine PhosphateSYNCI
  • ESTRAMUSTINE PHOSPHATE SODIUMPTFDA75F375MT2N
  • Ro-21-8837/001CNNCI
  • Leo 299SYDTPNSC0089199
  • EmcytBRNCI
  • Estramustine phosphateSYDTPNSC0089199
  • Estramustine sodium phosphateSYDTPNSC0702294
  • EstracytSYDTPNSC0089199
  • Leo-299CNNCI
  • Estramustine Sodium PhosphateSYNCI
  • Estramustine Phosphate SodiumPTNCI
  • EstracytFBNCI
  • Estramustine 17-(Dihydrogenphosphate) Disodium SaltSNNCI
DEFINITION
  • The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects.NCI
code
  • C480
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