About: Cefadroxil Hemihydrate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cefadroxil Hemihydrate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cefadroxil Hemihydrate
UMLS_CUI
  • C1707321
CAS_Registry
  • 119922-85-9
FDA_UNII_Code
  • J9CMF6461M
Contributing_Source
  • FDA
Chemical_Formula
  • 2C16H17N3O5S.H2O
Legacy_Concept_Name
  • Cefadroxil_Hemihydrate
FULL_SYN
  • Cefadroxil HemihydratePTNCI
  • CEFADROXIL HEMIHYDRATEPTFDAJ9CMF6461M
DEFINITION
  • The hemihydrate form of cefadroxil, a semi-synthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cefadroxil hemihydrate binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.NCI
code
  • C47965
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