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AttributesValues
rdf:type
rdfs:label
  • Zonisamide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Zonisamide
UMLS_CUI
  • C0078844
CAS_Registry
  • 68291-97-4
FDA_UNII_Code
  • 459384H98V
Contributing_Source
  • FDA
Chemical_Formula
  • C8H8N2O3S
Legacy_Concept_Name
  • Zonisamide
CHEBI_ID
  • CHEBI:10127
FULL_SYN
  • 1,2-Benzisoxazole-3-methanesulfonamideSNNCI
  • ZONISAMIDEPTFDA459384H98V
  • ExcegramSYNCI
  • ZonegranBRNCI
  • ZonisamidePTNCI
DEFINITION
  • A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA)/benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission.NCI
code
  • C47790
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