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AttributesValues
rdf:type
rdfs:label
  • Tromethamine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Tromethamine
NSC_Code
  • 6365
  • 65434
UMLS_CUI
  • C0041175
CAS_Registry
  • 77-86-1
FDA_UNII_Code
  • 023C2WHX2V
Contributing_Source
  • FDA
Chemical_Formula
  • C4H11NO3
Legacy_Concept_Name
  • Tromethamine
CHEBI_ID
  • CHEBI:9754
FULL_SYN
  • TROMETHAMINEPTFDA023C2WHX2V
  • 1,3-Propanediol, 2-Amino-2-(hydroxymethyl)-SNNCI
  • Tris BufferSYNCI
  • Tris(hydroxymethyly)amino MethaneSNNCI
  • TromethaminePTNCI
  • AminotrimethylolmethaneSYNCI
  • TRISSYNCI
  • ThamBRNCI
  • Tris-baseSYNCI
  • Tris(hydroxymethyl)aminomethaneSNNCI
  • TrometamolSYNCI
DEFINITION
  • A member of the pyrrolo-pyrrole group of non-steroidal anti-inflammatory drugs (NSAID) with analgesic, anti-inflammatory, and anti-pyretic properties. Tromethamine inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins. When inhibiting COX2, tromethamine may be effective in relieving pain and inflammation; when inhibiting COX1, this agent may produce unacceptable gastrointestinal side effects.NCI
code
  • C47775
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