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AttributesValues
rdf:type
rdfs:label
  • Tranexamic Acid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tranexamic Acid
NSC_Code
  • 291305
UMLS_CUI
  • C0040613
CAS_Registry
  • 1197-18-8
FDA_UNII_Code
  • 6T84R30KC1
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 453549
PDQ_Closed_Trial_Search_ID
  • 453549
Chemical_Formula
  • C8H15NO2
Legacy_Concept_Name
  • Tranexamic_Acid
CHEBI_ID
  • CHEBI:48669
FULL_SYN
  • Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, trans-SNNCI
  • CyclokapronFBNCI
  • CyklokapronBRNCI
  • TRANEXAMIC ACIDPTFDA6T84R30KC1
  • Tranexamic AcidPTNCI
  • Tranhexamic AcidSYNCI
  • LystedaBRNCI
DEFINITION
  • A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen, tranexamic acid competitively inhibits the activation of plasminogen to plasmin, resulting in inhibition of fibrinolysis; at higher concentrations, this agent noncompetitively inhibits plasmin. This agent has a longer half-life, is approximately ten times more potent, and is less toxic than aminocaproic acid, which possesses similar mechanisms of action.NCI
code
  • C47765
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