About: Tocainide Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tocainide Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tocainide Hydrochloride
NSC_Code
  • 130820
  • 169863
  • 62103
UMLS_CUI
  • C0886765
CAS_Registry
  • 35891-93-1
  • 71395-14-7
FDA_UNII_Code
  • 2K7I38CKN5
Contributing_Source
  • FDA
Chemical_Formula
  • C11H16N2O.HCl
Legacy_Concept_Name
  • Tocainide_Hydrochloride
FULL_SYN
  • Tocainide HydrochloridePTNCI
  • Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, MonohydrochlorideSNNCI
  • TOCAINIDE HYDROCHLORIDEPTFDA2K7I38CKN5
  • TonocardFBNCI
  • TaquidilSYNCI
  • XylotocanSYNCI
DEFINITION
  • The hydrochloride salt form of tocainide, a primary amine analog of lidocaine exhibiting class 1b antiarrhythmic property. Tocainide hydrochloride stabilizes the neuronal membrane by reversibly binding to and blocking open and inactivated voltage-gated sodium channels. This inhibits the inward sodium current required for the initiation and conduction of impulses and reduces the excitability of myocardial cells. This agent reduces the rate of rise and amplitude, and shortens the action-potential duration (APD) in both the Purkinje and muscle fibers. Tocainide also shortens the effective refractory period (ERP) of Purkinje fibers resulting in an increased the ERP/APD ratio. Overall these effects lead to the slowing of nerve impulses and stabilization of the heartbeat.NCI
code
  • C47761
is Has_Salt_Form of
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