About: Tizanidine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tizanidine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tizanidine Hydrochloride
UMLS_CUI
  • C0771735
CAS_Registry
  • 64461-82-1
FDA_UNII_Code
  • B53E3NMY5C
Contributing_Source
  • FDA
Chemical_Formula
  • C9H8ClN5S.HCl
Legacy_Concept_Name
  • Tizanidine_Hydrochloride
FULL_SYN
  • 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole HydrochlorideSNNCI
  • Tizanidine HydrochloridePTNCI
  • TIZANIDINE HYDROCHLORIDEPTFDAB53E3NMY5C
  • 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, MonohydrochlorideSNNCI
  • ZanaflexBRNCI
DEFINITION
  • The hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine and increasing the inhibitory effect on alpha motor neurons and motor reflexes. Tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors and imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall, tizanidine hydrochloride causes muscle relaxation, reduces spasticity and antinociceptive effects.NCI
code
  • C47760
is Has_Salt_Form of
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