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AttributesValues
rdf:type
rdfs:label
  • Tiopronin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tiopronin
UMLS_CUI
  • C0025405
CAS_Registry
  • 1953-02-2
FDA_UNII_Code
  • C5W04GO61S
Contributing_Source
  • FDA
Chemical_Formula
  • C5H9NO3S
Legacy_Concept_Name
  • Tiopronin
FULL_SYN
  • Glycine, N-(2-mercapto-1-oxopropyl)-SNNCI
  • (2-Mercaptopropionyl)glycineSNNCI
  • TIOPRONINPTFDAC5W04GO61S
  • Thiolpropionamidoacetic AcidSYNCI
  • ThiolaBRNCI
  • TioproninPTNCI
DEFINITION
  • An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.NCI
code
  • C47758
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