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AttributesValues
rdf:type
rdfs:label
  • Timolol
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Timolol
UMLS_CUI
  • C0040233
CAS_Registry
  • 91524-16-2
FDA_UNII_Code
  • 817W3C6175
Contributing_Source
  • FDA
Chemical_Formula
  • 2C13H24N4O3S.H2O
Legacy_Concept_Name
  • Timolol
CHEBI_ID
  • CHEBI:60787
FULL_SYN
  • TIMOLOLPTFDA817W3C6175
  • BetimolBRNCI
  • TimololPTNCI
  • 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hemihydrate, (S)-SNNCI
  • TimololPTDCP30216
  • (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-olSNNCI
  • BlocadrenSYNCI
DEFINITION
  • A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis.NCI
code
  • C47757
is Has_Free_Acid_Or_Base_Form of
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