About: Terbutaline Sulfate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Terbutaline Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Terbutaline Sulfate
UMLS_CUI
  • C0591192
CAS_Registry
  • 23031-32-5
FDA_UNII_Code
  • 576PU70Y8E
Contributing_Source
  • FDA
Chemical_Formula
  • 2C12H19NO3.H2SO4
Legacy_Concept_Name
  • Terbutaline_Sulfate
CHEBI_ID
  • CHEBI:9450
FULL_SYN
  • (+-)-alpha-((tert-Butylamino)methyl)-3,5-dihydroxybenzyl Alcohol Sulfate(2:1)(salt)SNNCI
  • 1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol SulphateSNNCI
  • 1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, Sulfate(2:1)(salt)SNNCI
  • BretineBRNCI
  • Terbutaline SulfatePTNCI
  • BricanylSYNCI
  • TERBUTALINE SULFATEPTFDA576PU70Y8E
  • BrethaireBRNCI
  • BrethancerBRNCI
DEFINITION
  • The sulfate salt form of terbutaline, an ethanolamine derivative with bronchodilating and tocolytic properties. Terbutaline sulfate selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic cAMP production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids the relaxation of airway muscles. Terbutaline sulfate also increases mucociliary clearance and reduces release of inflammatory cell mediators.NCI
code
  • C47748
is Has_Salt_Form of
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