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AttributesValues
rdf:type
rdfs:label
  • Sibutramine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sibutramine Hydrochloride
UMLS_CUI
  • C0142278
CAS_Registry
  • 125494-59-9
FDA_UNII_Code
  • OGM0YHD1WF
Contributing_Source
  • FDA
Chemical_Formula
  • C17H26ClN.HCl.H2O
Legacy_Concept_Name
  • Sibutramine_Hydrochloride
FULL_SYN
  • Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)-, HydrochlorideSNNCI
  • Sibutramine HydrochloridePTNCI
  • SIBUTRAMINE HYDROCHLORIDEPTFDAOGM0YHD1WF
  • MeridiaBRNCI
  • BTS 54524CNNCI
  • HSDB 7209CNNCI
DEFINITION
  • The hydrochloride salt form of sibutramine, a phenethylamine derivative with appetite depressant property. Sibutramine hydrochloride metabolites M1 and M2 competitively inhibit the reuptake of norepinephrine, serotonin, and to a lesser degree dopamine by pre-synaptic nerve terminals, thereby promoting a sense of satiety, leading to a decrease in calorie intake, and possibly an increase in resting metabolic rate. This agent does not exhibit anticholinergic or antihistaminic effects.NCI
code
  • C47718
is Has_Salt_Form of
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