About: Propafenone Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Propafenone Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Propafenone Hydrochloride
NSC_Code
  • 37855
UMLS_CUI
  • C0282316
CAS_Registry
  • 34183-22-7
FDA_UNII_Code
  • 33XCH0HOCD
Contributing_Source
  • FDA
Chemical_Formula
  • C21H27NO3.HCl
Legacy_Concept_Name
  • Propafenone_Hydrochloride
CHEBI_ID
  • CHEBI:8466
FULL_SYN
  • Propafenone HydrochloridePTNCI
  • 2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone HydrochlorideSNNCI
  • PROPAFENONE HYDROCHLORIDEPTFDA33XCH0HOCD
  • 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, HydrochlorideSNNCI
  • RythmolBRNCI
  • BaxarytmonSYNCI
DEFINITION
  • The hydrochloride salt form of propafenone with class 1C antiarrhythmic effects. Propafenone hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby reducing sodium influx required for the initiation and conduction of impulses in Purkinje and myocardial cells. This agent produces a marked depression of phase 0 and prolonged effective refractory period in the atrio-ventricular nodal and His-Purkinje tissue, resulting in a profound decrease in excitability, conduction velocity and automaticity, thereby counteracting atrial and ventricular arrythmias.NCI
code
  • C47692
is Has_Salt_Form of
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