About: Procainamide Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Procainamide Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Procainamide Hydrochloride
NSC_Code
  • 27461
UMLS_CUI
  • C0699067
CAS_Registry
  • 614-39-1
FDA_UNII_Code
  • SI4064O0LX
Contributing_Source
  • FDA
Chemical_Formula
  • C13H21N3O.HCl
Legacy_Concept_Name
  • Procainamide_Hydrochloride
CHEBI_ID
  • CHEBI:8429
FULL_SYN
  • Pronestyl-SRSYNCI
  • Novocamid HydrochlorideSYNCI
  • Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-, MonohydrochlorideSNNCI
  • Procainamide HydrochloridePTNCI
  • PromineBRNCI
  • PROCAINAMIDE HYDROCHLORIDEPTFDASI4064O0LX
  • Procan SRBRNCI
  • PronestylBRNCI
DEFINITION
  • The hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction.NCI
code
  • C47687
is Has_Salt_Form of
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