About: Minocycline Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Minocycline Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Minocycline Hydrochloride
NSC_Code
  • 141993
UMLS_CUI
  • C0591806
CAS_Registry
  • 13614-98-7
FDA_UNII_Code
  • 0020414E5U
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 552699
PDQ_Closed_Trial_Search_ID
  • 552699
Chemical_Formula
  • C23H27N3O7.HCl
Legacy_Concept_Name
  • Minocycline_Hydrochloride
CHEBI_ID
  • CHEBI:50697
FULL_SYN
  • 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide MonohydrochlorideSNNCI
  • Minocycline HydrochloridePTNCI
  • Tri-minocyclineSYNCI
  • MINOCYCLINE HYDROCHLORIDEPTFDA0020414E5U
  • DynacinBRNCI
  • MinocinBRNCI
  • VectrinBRNCI
  • MinomaxSYNCI
  • MinomycinSYNCI
DEFINITION
  • The hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.NCI
code
  • C47622
is Has_Salt_Form of
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