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AttributesValues
rdf:type
rdfs:label
  • Metyrapone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Metyrapone
NSC_Code
  • 25265
UMLS_CUI
  • C0025876
CAS_Registry
  • 54-36-4
FDA_UNII_Code
  • ZS9KD92H6V
Contributing_Source
  • FDA
Chemical_Formula
  • C14H14N2O
Legacy_Concept_Name
  • Metyrapone
CHEBI_ID
  • CHEBI:44241
FULL_SYN
  • 2-Methyl-1,2-di-3-pyridinyl-1-propanonePTDCP02127
  • METYRAPONEPTFDAZS9KD92H6V
  • 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-SNNCI
  • MetopironeBRNCI
  • MetyraponePTNCI
DEFINITION
  • A pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol from 11-deoxycortisol and corticosterone from desoxycorticosterone in the adrenal gland. Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. In turn, continuing stimulation of adrenal gland by ACTH results in accumulation of corticoid precursors, 11-desoxycortisol and desoxycorticosterone. These metabolites are excreted in urine that maybe used as indicators for pituitary responsiveness.NCI
code
  • C47619
is Has_Free_Acid_Or_Base_Form of
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