About: Methyldopate Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Methyldopate Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Methyldopate Hydrochloride
UMLS_CUI
  • C0304527
CAS_Registry
  • 2508-79-4
FDA_UNII_Code
  • 7PX435DN5A
Contributing_Source
  • FDA
Chemical_Formula
  • C12H17NO4.HCl
Legacy_Concept_Name
  • Methyldopate_Hydrochloride
FULL_SYN
  • L-Tyrosine, 3-hydroxy-alpha-methyl-, Ethyl Ester, HydrochlorideSNNCI
  • Methyldopa Ethyl Ester HydrochlorideSYNCI
  • Methyldopate HydrochloridePTNCI
  • Aldomet Ester HydrochlorideSYNCI
  • L-3-(3,4-Dihydroxyphenyl)-2-methylalanine Ethyl Ester HydrochlorideSNNCI
  • METHYLDOPATE HYDROCHLORIDEPTFDA7PX435DN5A
DEFINITION
  • The hydrochloride salt form of methyldopa, a phenylalanine derivate and aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.NCI
code
  • C47617
is Has_Salt_Form of
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