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AttributesValues
rdf:type
rdfs:label
  • Methyldopa
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Methyldopa
NSC_Code
  • 169916
UMLS_CUI
  • C0025741
CAS_Registry
  • 41372-08-1
FDA_UNII_Code
  • 56LH93261Y
Contributing_Source
  • FDA
Chemical_Formula
  • 2C10H13NO4.3H2O
Legacy_Concept_Name
  • Methyldopa
CHEBI_ID
  • CHEBI:61058
FULL_SYN
  • 3-Hydroxy-alpha-methyl-L-tyrosineSNNCI
  • Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanineSNNCI
  • MethyldopaPTDCP32050
  • L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic AcidSNNCI
  • AmodopaBRNCI
  • AldometBRNCI
  • DopametBRNCI
  • METHYLDOPAPTFDA56LH93261Y
  • MethyldopaPTNCI
DEFINITION
  • A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.NCI
code
  • C47616
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