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AttributesValues
rdf:type
rdfs:label
  • Hetacillin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Hetacillin
UMLS_CUI
  • C0062587
CAS_Registry
  • 3511-16-8
FDA_UNII_Code
  • TN4JSC48CV
Contributing_Source
  • FDA
Chemical_Formula
  • C19H23N3O4S
Legacy_Concept_Name
  • Hetacillin
CHEBI_ID
  • CHEBI:5683
FULL_SYN
  • PhenazacillinSYNCI
  • N,N'-Isopropylidene-A-amino-benzyl PenicillinSNNCI
  • 6-(2,2-Dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic AcidSNNCI
  • HETACILLINPTFDATN4JSC48CV
  • VersapenBRNCI
  • HetacillinPTNCI
DEFINITION
  • A semi-synthetic penicillin compound with bactericidal properties. Hetacillin is a prodrug that is converted to ampicillin via esterases. Ampicillin binds to inactivated penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs, including transpeptidases, carboxypeptidases, and endopeptidases, participate in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This results in the weakening of the bacterial cell wall and eventually causes cell lysis. (NCI05)NCI
code
  • C47555
is Has_Free_Acid_Or_Base_Form of
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