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AttributesValues
rdf:type
rdfs:label
  • Dofetilide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dofetilide
UMLS_CUI
  • C0114771
CAS_Registry
  • 115256-11-6
FDA_UNII_Code
  • R4Z9X1N2ND
Contributing_Source
  • FDA
Chemical_Formula
  • C19H27N3O5S2
Legacy_Concept_Name
  • Dofetilide
CHEBI_ID
  • CHEBI:4681
FULL_SYN
  • beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidideSNNCI
  • Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl-SNNCI
  • TikosynBRNCI
  • DOFETILIDEPTFDAR4Z9X1N2ND
  • DofetilidePTNCI
DEFINITION
  • A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.NCI
code
  • C47499
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