About: Diltiazem Malate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Diltiazem Malate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Diltiazem Malate
UMLS_CUI
  • C1165286
CAS_Registry
  • 144604-00-2
FDA_UNII_Code
  • 14Y6444DRP
Contributing_Source
  • FDA
Chemical_Formula
  • C22H26N2O4S.C4H6O5
Legacy_Concept_Name
  • Diltiazem_Malate
FULL_SYN
  • DILTIAZEM MALATEPTFDA14Y6444DRP
  • Diltiazem MalatePTNCI
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-,(S)-hydoxybutanedioate(1:1)SNNCI
  • TiamateBRNCI
DEFINITION
  • A malate salt of diltazem, a benzothiazepine calcium channel blocking agent. Diltiazem inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.NCI
code
  • C47493
is Has_Salt_Form of
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