About: Cefditoren Pivoxil     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cefditoren Pivoxil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cefditoren Pivoxil
UMLS_CUI
  • C0245519
CAS_Registry
  • 117467-28-4
FDA_UNII_Code
  • 78THA212DH
Contributing_Source
  • FDA
Chemical_Formula
  • C25H28N6O7S3
Legacy_Concept_Name
  • Cefditoren_Pivoxil
CHEBI_ID
  • CHEBI:560555
FULL_SYN
  • ME 1207CNNCI
  • Cefditoren PivoxilPTNCI
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((1Z)-2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-,2,2-dimethyl-1-oxopropoxy)methyl Ester,(6R,7R)-SNNCI
  • CEFDITOREN PIVOXILPTFDA78THA212DH
  • CCRIS 7768CNNCI
  • SpectracefBRNCI
DEFINITION
  • A semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis. Another consequence of beta-lactam exposure results in the loss of lipoteichoic acids from the cell wall. Lipoteichoic acids inhibit murein hydrolase activity and their absence from the cell wall triggers uncontrolled autolytic activity rendering bacterial cells susceptible to osmotic shock. This results in a reduction of cell wall stability and causes cell lysis.NCI
code
  • C47434
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