About: Carboprost Tromethamine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Carboprost Tromethamine
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Carboprost Tromethamine
UMLS_CUI
  • C0054721
CAS_Registry
  • 58551-69-2
FDA_UNII_Code
  • U4526F86FJ
Contributing_Source
  • FDA
Chemical_Formula
  • C21H36O5.C4H11NO3
Legacy_Concept_Name
  • Carboprost_Tromethamine
CHEBI_ID
  • CHEBI:3404
FULL_SYN
  • Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-,(5Z,9-alpha,11-alpha,13E,15S)-, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1)SNNCI
  • Carboprost TromethaminePTNCI
  • (15S)-15-Methylprostaglandin F(sub 2alpha) TromethamineSYNCI
  • CARBOPROST TROMETHAMINEPTFDAU4526F86FJ
  • (15S)-9a, 11a, 15-Trihydroxy-15-methyl-prosta-cis-5, trans-13-dienoic Acid Tromethamine SaltSNNCI
  • HemabateBRNCI
DEFINITION
  • The tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively.NCI
code
  • C47433
is Has_Salt_Form of
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